Will a M+B key 8x Sata card work in a M key socket?

2-2280 into slot two To begin, gently slide the SSD into the SSD slot on the system board

SATA SSD · -34% WD Green 240GB Internal SSD WDS240G3G0B · -23%

m2 slot types 2 PCIe slot, an SATA SSD with identical keying will fit in the slot but will not work, and vice versa There are some systems that are dual-mode,

m2 slot pc DDR5 · DDR4 Memory Slots 8 · 6 · 4 · 2 Graphics Interface PCIe · PCIe · PCIe PCIe x 16 Slots 7 · 6 · 5 · 4 · 3 · 2 · 1 SSD Slots 5 x